Singapore Optometric Association

IMI – Clinical Myopia Control Trials and Instrumentation Report

The evidence-basis based on existing myopia control trials along with the supporting academic
literature were reviewed; this informed recommendations on the outcomes suggested from
clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and
the impact on patients. These outcomes were classified as primary (refractive error and/or axial
length), secondary (patient reported outcomes and treatment compliance), and exploratory
(peripheral refraction, accommodative changes, ocular alignment, pupil size, outdoor activity/
lighting levels, anterior and posterior segment imaging, and tissue biomechanics). The currently
available instrumentation, which the literature has shown to best achieve the primary and
secondary outcomes, was reviewed and critiqued. Issues relating to study design and patient
selection were also identified. These findings and consensus from the International Myopia
Institute members led to final recommendations to inform future instrumentation development
and to guide clinical trial protocols.

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